Sudden cardiac arrest is the single condition causing the most deaths in the Western world. An estimated 375,000 people in Europe and 275,000 in the USA are victims of sudden cardiac arrest each year. The great majority of these cases occur out of the hospital. In Sweden, about 10,000 people suffer sudden cardiac arrest each year, and is the cause of over 10% of all deaths. 
Norwegian inventor Willy Vistung was inspired to develop a mechanical device for chest compressions while riding in an ambulance in Oslo. As the ambulance speed through the city, one paramedic tried to give chest compressions to a cardiac arrest patient as another tried to perform ventilation, both while kneeling over the patient and losing their balance every time they quickly turned a corner. When he saw these conditions, he thought there must be a better way, not only to guarantee the best possible treatment for the patient but also for the safety and health of the paramedics. 
In 1995, Vistung visited Stig Steen at Lund University Hospital to present a prototype for a mechanical chest compression device he had developed. Tragically, Vistung died shortly afterwards. In agreement with his widow, Steen decided to continue with the project. After developing several different prototypes, one was introduced in clinical practice at Lund University Hospital in 2000. It was given the name LUCUS, which stands for Lund University Cardiopulmonary Assist System. It is an automatic CPR-device that provides adequate and uninterrupted chest compression and active decompression at a rate of 100 strokes per minute, following the latest international guidelines in cardiopulmonary resuscitation. The first scientific report on its properties was published in 2002.  Since then, our research group has published several other studies on LUCAS. [3,4,5,6,7,8,9,10]
LUCAS not only offers improved treatment to patients, but also allows for safer working conditions for ambulance personal. The machine is strapped around the patient before being placed in the ambulance, who then receives constant, uninterrupted mechanical treatment while on the way to the hospital. During this time, the paramedic can offer other treatment and coordinate with hospital personal, all while safely buckled in.
Today, with more than 25,000 distributed worldwide, every 90 seconds a LUCAS is working tirelessly trying to save the life of a cardiac arrest victim.
The research leading to LUCAS has also allowed recent exploration of how to optimize ventilation during ongoing CPR with the objective to prevent damage to the heart by ensuring adequate blood flow through its arteries. Our contribution is a ventilation method that is phase locked to the LUCAS chest compressions in a way that acids perfusion of the heart. In a recently submitted paper the method, abbreviated PIIO, was compared with the best known pre-existing method, and found to produce significantly higher perfusion pressures without introducing other adverse effects. 
Liao, Qiuming. “LUCAS-Lund University Cardiopulmonary Assist System”. Lund University, Faculty of Medicine Doctoral Dissertation Series 2011:34
Steen S, Liao Q, Pierre L, Paskevicius A, Sjöberg T. Evaluation of LUCAS, a new device for automatic mechanical compression and active decompression resuscitation. Resuscitation 2002;55:285-299
Steen S, Liao Q, Pierre L, Paskevicius A, Sjöberg T. The critical importance of minimal delay between chest compressions and subsequent defibrillation: a haemodynamic explanation. Resuscitation 2003;58:249-258
Steen S, Liao Q, Pierre L, Paskevicius A, Sjoberg T. Continuous intratracheal insufflation of oxygen improves the efficacy of mechanical chest compression-active decompression CPR. Resuscitation 2004;62:219-227
Steen S, Sjöberg T, Olsson P, Young M. Treatment of out-of-hospital cardiac arrest with LUCAS, a new device for automatic mechanic compression. Resuscitation 2005;67:125-130
Frenneaux M, Steen S. Hemodynamics of cardiac arrest. In: Cardiac arrest. The science and practice of resuscitation medicine, 2nd edition. Eds: Paradis NA, Halperin HR, Kern KB, Wenzel V, Chamberlain DA. Cambridge University Press. 2007: 347-368
Kern KB, Niemann JT, Steen S. Coronary perfusion pressure during cardiopulmonary resuscitation. In: Cardiac arrest. The science and practice of resuscitation medicine, 2nd edition. Eds: Paradis NA, Halperin HR, Kern KB, Wenzel V, Chamberlain DA. Cambridge University Press. 2007: 369-389
Chamberlain D, Frenneaux M, Steen S, Smith A. Why do chest compressions aid delayed defibrillation. Resuscitation 2008;77.10-15
Liao Q, Sjöberg T, Paskevicius A, Wohlfart B, Steen S. Manual versus mechanical cardiopulmonary resuscitation. An experimental study in pigs. BMC Cardiovascular Disorders 2010, 10:53 (http://biomedcentral.com/1471-2261/10/53)
Wagner H, Madsen Härdig B, Friberg H, Steen S, Sjöberg T, Harnek J, Olivecrona G. Evaluation of coronary blood flow velocity during cardiac arrest with circulation maintained through mechanical chest compressions in a porcine model. BMC Cardiovascular Disorders 2011, 11:73 (http://biomedcentral.com/1471-2261/10/73).
Kristian Soltesz, Audrius Pascevicius, Henry Pigot, Qiuming Liao, Trygve Sjoberg, Stig Steen.. "Phase-controlled intermittent intratracheal insufflation of oxygen during chest compression-active decompression mCPR improves coronary perfusion pressure over continuous insufflation”. Resuscitation. In submission.